Saloxicin

This formula supports eicosanoid and cytokine balance and provides support for joint comfort. These molecules are produced by the body during injury and inflammation. Salicin is a natural product to support the body’s normal response to inflammation and provide relief from pain and discomfort.

White Willow Bark: Willow bark has been used for thousands of years to help support eicosanoid and cytokine balance and to help relieve discomfort [1-3]. Willow bark is currently approved by the German Commission E and the European Scientific Cooperative on Phytotherapy (ESCOP) for these purposes. Willow bark is also recognized in the United States for its role in supporting joint comfort [1]. Various randomized placebo-controlled studies suggest that willow bark produces positive effects on joint discomfort. The usual dose of salicin is 240 mg per day [4].

5•Loxin®: A standardized Boswellia serrata extract enriched to 30% 3-O-acetyl-11-keto-ß-boswellic acid (AKBA), is ten times more concentrated than ordinary Boswellia serrata. Boswellia serrata is an ayurvedic herb whose principle constituents—boswellic acid and alpha-boswellic acid—may help maintain healthy leukotriene metabolism by reducing the activity of the enzyme 5-lipoxygenase [5]. 5-lipoxygenase (5-LOX) catalyzes the synthesis of unfavorable leukotrienes. A randomized, double-blind, placebo-controlled trial assessing the efficacy, safety, and tolerability of Boswellia extract produced statistically significant and clinically relevant decreases in knee discomfort, increases in knee flexion, and increases in walking distance [6]. A randomized, double-blind, placebo-controlled study specifically designed with 5•Loxin resulted in statistically significant improvements in comfort and physical function and a significant reduction in matrix metalloproteinase (MMP) in synovial fluid [7].

BerryVin™ (40 mg): Contains a blend of blueberries, strawberries, escobillo, and cranberries, along with grape and pomegranate extracts. This bioflavonoid-rich berry powder provides polyphenols, anthocyanins, ellagic acid, and an antioxidant capacity of 4000 TE/g to fight free radicals.   

References

1. Natural Standard Database. Willow Bark (Salix Spp.). Somerville, MA: Natural Standard; 2012. http://naturalstandard.com/databases/herbssupplements/ willowbark.asp#undefined. Accessed August 2, 2012
2. Singh AP. Salicin-A natural analgesic. Ethnobotanical Leaflets. 2003;1:1-4. http://opensiuc.lib.siu.edu/ebl/vol2003/iss1/8. Accessed August 2, 2012.
3. Fiebich BL, Appel K. Anti-inflammatory effects of willow bark extract. Clin Pharmacol Ther. 2003 Jul;74(1):96; author reply 96-7. [PMID: 12844141]
4. Maroon JC, Bost JW, Maroon A. Natural anti-inflammatory agents for pain relief. Surg Neurol Int. 2010 Dec 13;1:80. [PMID: 21206541]
5. Safayhi H, Boden SE, Schweizer S, et al. Concentration-dependent potentiating and inhibitory effects of Boswellia extract on 5-Lipoxygenase product formation in stimulated PMNL. Planta Med. 2000 Mar;66(2):110-3. [PMID: 10763581]
6. Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee—a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7. [PMID: 12622457]
7. Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Arthritis Res Ther. 2008;10(4):R85. [PMID: 18667054]