Resveratrol PLUS

Resveratrol is found in varying amounts in grapes, various berries, plums, peanuts (and pines). Resveratrol is a stilbenol derived from stilbene, a natural plant product. Stilbenols are polyphenolic compounds that have cell-protecting properties [1]. Oral resveratrol is rapidly metabolized via sulfate conjugation by the intestine/liver [2].

Resveratrol has also shown ability to produce changes associated with longevity. These include increased insulin sensitivity, reduced IGF-1, increased AMP-activated protein kinase and peroxisome proliferator-activated receptor-gamma coactivator 1 alpha activity, increased mitochondrial number and improved motor function [3]. Resveratrol activates sirtuins including SIR2, a special longevity cellular [4] and SIRT1 that helps protect nerve cells [5].

Resveratrol’s numerous anti-inflammatory properties may explain why it has so many far-reaching health benefits. It inhibits synthesis and release of pro-inflammatory mediators, modifies eicosanoid synthesis, and inhibits activated immune cells [6].

Quercitin, pterostilbene and resveratrol are synergistic antioxidants, with quercitin seemingly aiding in the absorption of resveratrol [7]. Pterostilbene, a new focus of scientific research, is methylated resveratrol, a bio-optimized form that complements resveratrol and quercetin. These compounds are being extensively studied in the areas of cardiovascular health and aging.

Click on the following link to read more. Has the FOUNTAIN OF YOUTH Been Discovered? The Startling New Evidence!

References

1. Fresco P, Borges F, Diniz C, Marques MP. New insights on the anticancer properties of dietary polyphenols. Med Res Rev. 2006 Nov;26(6):747-66 [PMID: 16710860]
2. Wenzel E, Somoza V. Metabolism and bioavailability of trans-resveratrol. Mol Nutr Food Res. 2005 May;49(5):472-81. [PMID:15779070]
3. Baur JA, et al. Resveratrol improves health and survival of mice on a highcalorie diet. Nature. 2006 Nov; 16;444(7117):337-42. [PMID: 17086191]
4. Stefani M, et al. The effect of resveratrol on a cell model of human aging. Ann N Y Acad Sci. 2007 Oct;1114:407-18. [PMID: 17804521]
5. Tang BL, Chua CESIRT1 and neuronal diseases. Mol Aspects Med. 2008 Jun;29(3):187-200 [PMID: 17397914]
6. de la Lastra CA, Villegas I.Resveratrol as an anti-inflammatory and antiaging agent: mechanisms and clinical implications. Mol Nutr Food Res. 2005 May;49(5):405-30 [PMID:15832402]
7. Morimitsu Y, Sugihara N, Furuno K. Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations. Biol Pharm Bull. 2004 May;27(5):714-7. [PMID: 15133252]