HGH Stimulate Powder

This exciting formula is based on the latest Nobel Prize-winning research on nitric oxide, a naturally occurring compound in the body. Nitric oxide is an important messenger that signals a variety of responses at the cellular level which are beneficial to circulatory, immune, and nervous system functions. HGH Stimulate is a refreshing, effervescent powder that offers therapeutic levels of L-arginine and L-citrulline, two amino acids the body uses to make nitric oxide.

Nitric oxide (NO) is produced by various body cells from the amino acid L-arginine through the enzymatic action of nitric oxide synthase (NOS). NO has a critical role in regulating the function of organs and systems throughout the body. It is well known that NO production by vascular endothelium plays a critical role in blood flow regulation and that the abnormal production of NO can adversely affect blood flow, delivery of nutrients and oxygen, and other vascular functions.

L-Arginine: The principal substrate for the family of NOS enzymes that catalyze the biosynthesis of NO. Some of L-arginine’s benefits include support of immune response, ammonia detoxification, growth hormone secretion (during rest), improved exercise performance (at 6 g/d), wound healing, reduced platelet aggregation, and vasodilation [1,2]. New research also suggests that asymmetric dimethylarginine (ADMA) accumulation in oxidized low-density lipoproteins (OxLDL) may signal vascular smooth muscle cell (VSMC) migration, which plays a critical role in the etiology of intimal thickening of blood vessels and L-arginine markedly blocked ADMA-induced VSMC migration [3].

L-Citrulline: A precursor to L-arginine that readily permeates the intestinal wall and enters the bloodstream. L-citrulline is processed by the kidney, where it is converted to L-arginine; and oral L-citrulline supplementation in humans has been shown to increase plasma L-arginine availability for NO synthesis [4].

Quercetin: A bioflavonoid, naturally occurring in plants, which supports healthy cellular, endothelial, and a healthy immune function. This unique phytonutrient also supports healthy cholesterol levels already within normal range [5]. Quercetin also helps reduce oxidative stress, promotes a healthy inflammatory response in blood vessel walls as a result of healthy gene expression,⁷ and supports healthy blood glucose levels already within normal range [6-8].

Folic Acid (Folate): Research suggests that homocysteine may decrease the bioavailability of NO [9]. Folate’s ability to lower homocysteine levels may provide the added benefit of increasing NO levels through enhancing NO bioavailability. Another role of folic acid in NO production relates to tetrahydrobiopterin (THBP, also known as BH4)—an essential cofactor for NOS. Inadequate folate may impair the synthesis of THBP [10] and 5-MTHF (bioactive folate) may normalize the activity of NOS in THBP-depleted endothelial cells [11]. In a placebo-controlled study of patients receiving 400 mcg/d of folic acid for seven weeks before coronary artery bypass grafting, improved vascular function was observed and attributed to improved availability of THBP for NOS and reduced vascular oxidative stress [12].

Vitamins C and E: Free-radical injury reduces NO availability and antioxidants appear to preserve NO. In addition, healthy endothelial function is associated with low oxidative stress, particularly decreased superoxide production and reduced oxidized LDL (OxLDL), which, if elevated can reduce endothelium-derived NO activity. Vitamins C and E supplementation can reduce both superoxide and OxLDL, thereby improving NO activity [13]. In other research, the effect of alpha-tocopherol (vitamin E) seems to be dependent on tissue saturation with ascorbic acid (vitamin C) and both vitamins may act synergistically to provide optimal conditions for endothelial NO formation [14].

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CAUTIONS: Do NOT use if you have low blood pressure.

References

1. Böger RH. The pharmacodynamics of L-arginine. J Nutr. 2007 Jun;137(6 Suppl 2):1650S-55S. [PMID: 17513442]
2. Bailey SJ, Winyard PG, Vanhatalo A, et al. Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance. J Appl Physiol. 2010 Nov;109(5):1394-403. [PMID: 20724562]
3. Sun L, Zhang T, Yu X, et al. Asymmetric dimethylarginine confers the communication between endothelial and smooth muscle cells and leads to VSMC migration through p38 and ERK1/2 signaling cascade. FEBS Lett. 2011 Sep 2;585(17):2727-34. [PMID: 21821030]
4. Sureda A, Cordova A, Ferrer MD, et al. Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise. Free Radic Res. 2009 Sep;43(9):828-35. [PMID: 19585317]
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6. Clin Chem. 2000 Aug;46(8 Pt 1):1162-70.
7. Clin Chem. 2000 Aug;46(8 Pt 1):1162-70.
8. Clin Chem. 2000 Aug;46(8 Pt 1):1162-70.
9. Tawakol A, Forgione MA, Stuehlinger M, et al. Homocysteine impairs coronary microvascular dilator function in humans. J Am Coll Cardiol. 2002 Sep 18;40(6):1051-58. [PMID: 12354427]
10. Crabtree MJ, Channon KM. Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric Oxide. 2011 Aug 1;25(2):81-88. [PMID: 21550412]
11. McCarty MF. Coping with endothelial superoxide: potential complementarity of arginine and high-dose folate. Med Hypotheses. 2004;63(4):709-18. [PMID: 15325022]
12. Shirodaria C, Antoniades C, Lee J, et al. Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease. Circulation. 2007 May 1;115(17):2262- 70. [PMID: 17420345]
13. Carr A, Frei B. The role of natural antioxidants in preserving the biological activity of endothelium-derived nitric oxide. Free Radic Biol Med. 2000 Jun 15;28(12):1806-14. [PMID: 10946222]
14. Heller R, Werner-Felmayer G, Werner ER. Alpha-Tocopherol and endothelial nitric oxide synthesis. Ann N Y Acad Sci. 2004 Dec;1031:74-85. [PMID: 15753135]