Cortisol Buster

Cortisol Buster helps your body resist and recover from the effects of everyday stress. Components of this multifunctional formula have been shown to support healthy cortisol levels, help alleviate occasional fatigue, promote mental clarity, and support relaxation and restful sleep. This herbal formula helps the overstressed body and mind work toward their normal state of balance and resolve many of the biochemical changes that occur as a result of repeated, frequent exposure to stressors and cortisol.

Relora®: This is a patented and proprietary blend of bark extracts standardized to honokiol and berberine. These herbs have a history of traditional use in treating stress and occasional feelings of anxiousness. Human studies demonstrate positive changes in DHEA (dehydroepiandrosterone) and cortisol levels, less weight gain (compared to controls), and reductions in perceived stress and transitory feelings of anxiousness in subjects taking Relora® (500 mg to 750 mg for four to six weeks) [1-3]. As an example, cortisol exposure and psychological mood states were studied in 56 subjects (35 men and 21 women) taking Relora® (250 mg twice daily) or placebo. After four weeks of supplementation, salivary cortisol exposure was significantly lower in the Relora® group compared to placebo. The Relora® group also had significantly better mood state parameters, including lower indices of stress, tension, anger, occasional fatigue and confusion and higher indices of global mood state and vigor [2].

Ashwagandha: This herb has been revered as an adaptogen for thousands of years. It is used to balance, energize, and revitalize the body and for its value as a cognition enhancer. Sensoril® is an optimized ashwagandha root and leaf extract that represents a major advancement in ashwagandha preparations. This proprietary and patented extraction process produces very high, powerful levels of stress-fighting, cognition-enhancing ashwagandha bioactive constituents. Sensoril® possesses multiple health benefits, and its superior efficacy has been demonstrated in randomized, double-blind, placebo-controlled human clinical trials [4-6]. The results of these trials revealed that Sensoril®, taken in doses of 500 to 1000 mg/d, supported healthy cortisol and DHEA levels; enhanced working memory, reaction time, and cognitive capacity; improved auditory-verbal working memory; ameliorated negative changes in cardiovascular parameters associated with mental stress; and improved endothelial function and glucose and lipid metabolism.

Suntheanine®: This is a pure form of L-theanine that is produced via a patented fermentation process, resulting in a 100% pure L-isomertheanine. Clinical research suggests that 50 to 200 mg/d of Suntheanine® naturally stimulates activity in the brain known as alpha waves, which are associated with a relaxed but alert mental state [7]. In human studies, results were observed wherein L-theanine helped the body resist biochemical changes associated with stress [8,9]. In a randomized, double-blind, placebo controlled trial, a high dose of Suntheanine® (400 mg/d) given to boys, aged 8-12 years, improved aspects of sleep quality, including significantly higher sleep percentage and sleep efficiency scores as well as a non-significant trend for less activity during sleep [10].

References

1. LaValle JB, Hawkins EB. Botanicals in dietary supplements: Stress and anxiety: the potential benefit of a proprietary combination of magnolia and phellodendron extracts. Dana Point, CA: Integrative Health Resources; 2013:1-15. http://www.nextpharmaceuticals.com/stage/pdfs/Relora%20Article-2013-LaValle.pdf. Accessed February 22, 2015.
2. Talbott SM, Talbott JA, Pugh M. Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 Aug 7;10(1):37. [PMID: 23924268]
3. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med. 2006 Jan-Feb;12(1):50-54. [PMID: 16454147]
4. Chengappa KN, Bowie CR, Schlicht PJ, et al. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. J Clin Psychiatry. 2013 Nov;74(11):1076-83. [PMID: 24330893]
5. Auddy B, Hazra J, Mitra A, et al. A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans; a double-blind, randomized, placebo-controlled study. JANA. 2008;11(1):50-56. http://www.lifeforce. net/pdfs/withania_review.pdf. Accessed February 23, 2015.
6. Pingali U, Fatima N, Kumar CU, et al. Evaluation of a highly standardized Withania somnifera extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double blind, placebo controlled study. Int J Ayur Pharma Research. 2014;2(3):22-32. http://ijapr.in/articles/ research/231482.pdf. Accessed February 23, 2015.
7. Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8. [PMID: 18296328]
8. Unno K, Tanida N, Ishii N, et al. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress. Pharmacol Biochem Behav. 2013 Oct;111:128-35. [PMID: 24051231]
9. Yoto A, Motoki M, Murao S, et al. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. J Physiol Anthropol. 2012 Oct 29;31:28. [PMID: 23107346]
10. Pingali U, Fatima N, Kumar CU, et al. Evaluation of a highly standardized Withania somnifera extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double blind, placebo controlled study. Int J Ayur Pharma Research. 2014;2(3):22-32. http://ijapr.in/articles/ research/231482.pdf. Accessed February 23, 2015.